期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：19
期号：3
页码：165-173
DOI：10.3164/jcbn.19.165
出版社：The Society for Free Radical Research Japan
摘要：Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18mmol/liter) level within 48h of intravenous streptozotocin injection. The untreated diabetic rats exhibited a reduction in body weight gain, with a 50% increase in daily food intake. In diabetic animals treated with insulin for 4 weeks, the plasma glucose, body weight gain, and daily food intake were comparable to those of the non-diabetic controls. The plasma concentration of vitamin A was significantly reduced in the diabetic animals, whereas the hepatic content of vitamin A in them was significantly elevated. Treatment with implantable insulin resulted in both plasma and liver concentrations of vitamin A returning to the control non-diabetic levels. Dietary zinc supplementation (120μg/g diet for 4 weeks) failed to improve the plasma concentration of vitamin A. These results suggest that the impaired metabolic availability of vitamin A in the presence of diabetes is caused by insulin deficiency.
关键词：streptozotocin-induced diabetes;vitamin A status;insulin effect;dietary zinc effect
