期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：2
期号：1
页码：41-53
DOI：10.3164/jcbn.2.41
出版社：The Society for Free Radical Research Japan
摘要：The effect of a geometrical difference in dietary fat on mammary tumorigenesis was studied. Female Sprague-Dawley rats were fed a purified diet containing olive oil ( cis -monoene fat), partially hydrogenated corn oil ( trans -monoene fat), or a blend of these two oils at the 10% level and received a single oral dose of 7, 12-dimethylbenz(a)anthracene (DMBA). The difference in the fatty acid composition of dietary fats was confined to the geometry of octadecenoate with an appropriate supply of linoleic acid (2% of total energy). The latency period, the rate of the tumor incidence, and the tumor yield 20 weeks after DMBA treatment were all comparable among the three groups. The growth of transplantable mammary tumors in female Wistar rats fed 5% fat diets was also the same between trans - and cis -fat. In DMBA-treated rats, plasma eicosanoid (PGE1, PGE2, and TXB2) levels of the trans -fat groups tended to be higher, while the concentration of 6-keto-PGF1α was comparable. The trans -fat reduced the ratio of arachidonate to linoleate in plasma and liver, but apparently not tumor phosphatidylcholine. The results indicate that the trans -fat is at least equally effective as cis -fat in terms of mammary tumorigenesis.
