期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：2
期号：1
页码：101-110
DOI：10.3164/jcbn.2.101
出版社：The Society for Free Radical Research Japan
摘要：A solid-phase radioimmunoassay was developed for estimating antibody to myelin basic protein. Conditions of the various procedures were established for optimal specific antibody binding. Myelin basic protein was bound to microtiter plates, followed by incubation with diluted test serum. 125I-protein A was used to measure the IgG bound to the antigen-coated well. Sera from 47 patients with multiple sclerosis, cerebrovascular disease, neuro-Behçet's disease, and other neurological diseases were tested for antibody to myelin basic protein. Positive serum antibody was predominantly found in patients with significant basic protein antigen in their cerebrospinal fluids.
关键词：myelin basic protein;anti-myelin basic protein antibody;solid-phase radioimmunoassay;multiple sclerosis;neurological diseases
