期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：2
期号：2
页码：163-170
DOI：10.3164/jcbn.2.163
出版社：The Society for Free Radical Research Japan
摘要：The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by burn shock. After the immersion of rats in 80°C water for 10min, blood pressure was significantly decreased, and serum levels of lysosomal enzymes, such as acid phosphatase and β-glucuronidase were significantly increased. These findings indicate that the burned rats were in shock states. Blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in the body of the stomach. Thiobarbituric acid-reactive substances, an index of lipid peroxidation, in the serum and the gastric mucosa were significantly increased after the burn. These changes appeared before the severe injury of the gastric mucosa, indicating that lipid peroxidation plays a significant role in the pathogenesis of the gastric mucosal lesions induced by burn shock.
