期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：2
期号：3
页码：253-259
DOI：10.3164/jcbn.2.253
出版社：The Society for Free Radical Research Japan
摘要：Effects of pyridoxal 5′-phosphate on enzymatic reactions of cross-link formation in collagen and elastin were studied. In this study, we observed that pyridoxal 5′-phosphate combined with β-aminopropionitrile to competitively reverse the inhibition of activities of vitamin B6-dependent enzymes brought about by β-aminopropionitrile in vitro . In addition, we observed that a sufficient dose of pyridoxine hydrochloride prevented the occurrence of dissecting aneurysm of SD rats fed β-aminopropionitrile. From the above results, we assume that β-aminopropionitrile inhibited the lysyl oxidase by binding with the pyridoxal 5′-phosphate that is necessary for the activation of lysyl oxidase.
