期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1996
卷号：20
期号：2
页码：149-159
DOI：10.3164/jcbn.20.149
出版社：The Society for Free Radical Research Japan
摘要：Serum fatty acid compositions and serum lipid concentrations in workers residing in five different metropolitan areas were compared by sex, age group, and region; and their correlations were studied. The proportion of C18:2 was the largest among polyunsaturated fatty acids (PUFA) in both males and females in any age group, and the proportion of n-3 PUFA was less than one fifth of that of n-6 PUFA. The proportion of C18:2 was significantly larger in females than males. On the other hand, the proportions of C20:5, C22:6, and n-3 PUFA increased in both sexes in their 20 to 40s, but showed no significant changes in the older groups. The P/S ratio was significantly higher in females than in males. The n-3/n-6 ratio was lowest in both sexes in their 20s (0.11-0.12), and increased with advancing age. There were no differences between the sexes in the mean serum total cholesterol (TC) concentration. The serum triglyceride (TG) concentration was higher in males than females. Serum TC showed weak positive Correlations with the proportion of n-3 PUFA and the n-3/n-6 ratio. In contrast, serum TG showed a strong positive correlation with C18:1 and negative correlations with the proportion of n-6 PUFA and the P/S ratio. The study suggests that, in healthy humans with normal serum TC and TG, TG concentration responded more strongly than TC concentration to n-6 PUFA, which is predominant in serum.
