期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：22
期号：1
页码：19-29
DOI：10.3164/jcbn.22.19
出版社：The Society for Free Radical Research Japan
摘要：systemic endotoxemia and its relation to the fibrotic process were studied in two forms of hepatic disorders in experimental animals. The first was bilharzial liver disease, and the second was CCl4-induced cirrhosis. Endotoxin results were correlated with total hepatic collagen and tissue fibronectin, which are two indices of the fibrotic process. In schistosome-infested hamsters, early significant progressive elevation of plasma endotoxin was detected 6 weeks post-infestation and was correlated with significantly elevated total hepatic collagen and tissue fibronectin. In rats with CCl4-induced cirrhosis, significant rise in plasma endotoxin, total hepatic collagen, and tissue fibronectin was observed at the 10th week after injections. We noticed that removal of intestinal endotoxins by neomycin administration, induction of endotoxin tolerance, or enhancement of macrophage functions by interferon (IFN) injections resulted in significant lower levels of systemic endotoxemia and fibrogenesis in both rats and hamsters.
