期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：22
期号：2
页码：77-89
DOI：10.3164/jcbn.22.77
出版社：The Society for Free Radical Research Japan
摘要：The influence of intragastric corn peptide (CP) administration on plasma amino acid concentrations and alcohol metabolism was investigated in stroke-prone spontaneously hypertensive rats that were given CP and ethanol intragastrically through a gastric tube or CP alone intragastrically at a dose of 1.0g/kg. CP administered with ethanol significantly elevated the plasma free amino acid concentrations, especially those of alanine, leucine, and proline; and these concentrations reached their maximum at 30min after CP intake. Furthermore, a significant reduction in the increase in blood ethanol concentration was observed. CP administered alone also elevated the concentrations of the same amino acids, and these reached their maximum level at 90min after CP intake when ethanol was given intraperitoneally. In this case, the reduction in the increase in blood ethanol concentration was not observed. Accordingly, these results suggest that CP is effectively absorbed into the system through the intestinal tract in coexistence with ethanol and the elevation in plasma amino acids, alanine, leucine, and proline levels may prevent the increase in blood ethanol concentration after ethanol intake due to the enhancement of alcohol metabolism.
