期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：22
期号：2
页码：125-129
DOI：10.3164/jcbn.22.125
出版社：The Society for Free Radical Research Japan
摘要：Lung fibrosis was induced in rats by exposing them to fractionated irradiation, bleomycin instillation into the lung, or paraquat treatment. Lung lipid peroxides, serum lipid peroxides, and lung collagen hydroxyproline were found to be significantly elevated (>100%) in rats after exposure to these agents over a period ranging from 25 days to 60 days. Antioxidants curcumin, ellagic acid, bixin, and α-tocopherol reduced significantly the serum and lung lipid peroxides. Consequent to the decrease in peroxides, lung collagen hydroxyproline was reduced to almost the normal level in these animals. These results indicate the usefulness of the above non-toxic antioxidants in conditions of lung fibrosis produced by various xenobiotic agents.
