期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：22
期号：3
页码：149-154
DOI：10.3164/jcbn.22.149
出版社：The Society for Free Radical Research Japan
摘要：The flavonoid quercetin was assessed for its chemopreventive property in Sarcoma-180(S-180)-induced ascites tumors. The flavonoid was administered in the diet at 2% level to S-180-bearing mice, and the lipid and lipoprotein profile was studied after the treatment. The plasma cholesterol levels increased in the S-180-bearing mice, with the increase attributed to LDL and VLDL; whereas HDL showed a decrease in the S-180-bearing animals. However on administration of quercetin there was a significant decrease in the cholesterol (free, total and ester) and lipoprotein levels (LDL and VLDL) with a corresponding increase in HDL cholesterol. The cholesterol levels of S-180 ascites fluid were also decreased in the quercetin-treated S-180 tumor.
