期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1999
卷号：26
期号：2
页码：155-160
DOI：10.3164/jcbn.26.155
出版社：The Society for Free Radical Research Japan
摘要：Diabetes mellitus is a chronic, systemic, metabolic disease defined by hyperglycemia and characterized by alterations in the metabolism of carbohydrate, protein, and lipid. The cumulative effects of these metabolic derangements lead to cell damage, circulatory changes, and eventually to cardiovascular disorders, including increased plasma lipoproteins, atherosclerosis, hypertension, and cardiomyopathy. Other clinical consequences of diabetes include nephropathy, neuropathy, and retinopathy. The latter can reach a proliferative phase associated with neovascularization of retinal vessels, vitreous hemorrhage and retinal detachment; this, in fact, is the leading cause of visual impairment and blindness in adults. Visual defects are also known to be a clinical consequence of vitamin A deficiency. Evidence to date point to the fact that diabetes is associated with an impaired metabolic availability of the vitamin. This paper delineates the link between insulin-dependent diabetes mellitus (IDDM) (Type I) and the biochemical evidence of vitamin A deficiency.
关键词：insulin-dependent diabetes;vitamin A metabolism;retinol-binding protein;transthyretin
