期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2000
卷号：28
期号：3
页码：217-232
DOI：10.3164/jcbn.28.217
出版社：The Society for Free Radical Research Japan
摘要：Glycosylation represents a major posttranslational modification reaction of proteins and plays a pivotal role in a variety of cellular events. N -Acetylglucosaminyltransferases III (GnT-III) and V (GnT-V), and α 1-6 fucosyltransferase are key enzymes in the processing of N-linked glycoproteins, and are heavily involved in cancer progression and metastasis. Very recently we also found that GnT-III is capable of reducing or masking the expression of the αGal epitope, which is a major xenoantigen in swine to human xenotransplantation. In this minireview we focus on the role of the above glycosyltransferases in cancer metastasis as well as in xenotransplantation.
关键词：N-acetylglucosaminyitransferases III and V;α 1-6 fucosyltransferase;cancer;xenotransplantation
