期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：3
期号：2
页码：95-102
DOI：10.3164/jcbn.3.95
出版社：The Society for Free Radical Research Japan
摘要：The effects of dietary supplements of β-carotene (20-500mg per kg diet) on hepatic microsomal drug-metabolizing enzyme activities were studied in mice. Supplementation for 14 days resulted in marked reductions in the concentrations of cytochrome P-450 and biphenyl 4-hydroxylase. The antipyrine N-demethylase and p -nitroanisol O-demethylase activities, however, were unchanged. Also apparently unchanged were the hepatic concentrations of microsomal protein, lipid peroxides, and superoxide dismutase. Supplemental β-carotene was weakly protective against the acute toxic effects of an injection of 1, 2-dimethylhydrazine (DMH), as indicated by a lowered mortality. This anti-carcinogenic action of β-carotene, including a protection against DMH-induced colon carcinogenesis, suggests an alteration by this carotenoid in the metabolism of carcinogens by the liver.
