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  • 标题:Erythrocyte Arginase as an Inhibitor in Thrombus Formation
  • 本地全文:下载
  • 作者:Michihiko HAYAKAWA ; Fumio KUZUYA ; Yoshio IWATA
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:1987
  • 卷号:3
  • 期号:2
  • 页码:135-142
  • DOI:10.3164/jcbn.3.135
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:Arginase activity in the erythrocyte showed lower values in cases of cerebral and myocardial infarctions than in normal cases. To explore this phenomenon we studied the effect of arginase on platelet aggregation. It was demonstrated that the arginase possesses the inhibitory activity toward platelet aggregation: it inhibits the formation of the platelet-thrombus due to arachidonic acid in vivo by raising its concentration in the erythrocyte. Thus it appears that the arginase in erythrocytes is concerned with the inhibition of thrombus formation.
  • 关键词:thrombosis;erythrocyte;arginase;platelet aggregation
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