期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：3
期号：3
页码：189-193
DOI：10.3164/jcbn.3.189
出版社：The Society for Free Radical Research Japan
摘要：It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O-2 in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O-2 in ulcer formation in the stomach.
