期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：3
期号：3
页码：195-199
DOI：10.3164/jcbn.3.195
出版社：The Society for Free Radical Research Japan
摘要：4-Aminopyrazolopyrimidine (4-APP)-induced fatty livers were analyzed biochemically and immunohistochemically. Biochemically, lipid peroxide levels measured by thiobarbituric acid method in the rat liver homogenates were markedly increased following 4-APP administration. However, glutathione peroxidase (GSH-PO) activity in the same homogenates was decreased. In addition, immunohistochemical localization of GSH-PO in 4-APP-treated rat liver was also decreased. Based on our data, we strongly suggested that pathogenesis of 4-APP induced-fatty liver may be due to uncontrolled free radical formation, peroxidation of lipids, and an associated lipid accumulation in the liver.
