期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2002
卷号：31
页码：37-43
DOI：10.3164/jcbn.31.37
出版社：The Society for Free Radical Research Japan
摘要：A study was conducted to determine whether the catabolism of an intravenously injected fat emulsion could be correlated with lipoprotein lipase (LPL) mass and activity in postheparin plasma. We observed the relationship between the fractional removal rate ( K 2) of an intravenously injected fat emulsion (Intralipid®) and LPL mass and activity in postheparin plasma of 20 normolipidemic and 21 hypertriglyceridemic subjects. The K 2 level was determined by the intravenous fat emulsion tolerance test. LPL mass was measured by a sandwich enzyme immunoassay system. K 2 was significantly correlated with the LPL mass in total group of subjects ( r =0.51, p <0.001), as well as in normolipidemic ( r =0.72, p <0.001) and hypertriglyceridemic ( r =0.43, p <0.05) subgroups. K 2 was also significantly correlated with LPL activity in the total group ( r =0.40, p <0.05), as well as in the normolipidemic subjects ( r =0.55, p <0.05). Kinetics following an intravenous injection of a fat emulsion reflect LPL mass and activity in postheparin plasma.
关键词：fat emulsion kinetics;lipoprotein lipase in postheparin plasma;Intralipid®;fat emulsion tolerance test;triglyceride
