标题：An Angiotensin-Converting Enzyme Inhibitor Suppresses the Expression of Vascular Cell Adhesion Molecule-1 and Production of Cytokines Induced in Activated Endothelial Cells
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2002
卷号：32
页码：43-54
DOI：10.3164/jcbn.32.43
出版社：The Society for Free Radical Research Japan
摘要：Quinaprilat, an angiotensin-converting enzyme (ACE) inhibitor, is commonly used for the therapy of hypertension, but the influence of ACE inhibitor for the atherogenesis has not been clear. Then we investigated the suppressive effect of ACE inhibitor on the expression of adhesion molecules and the production of cytokines which play an important role in the early development of atherosclerosis in endothelial cells (ECs). Quinaprilat treatment significantly reduced the activation of nuclear factor-κB (NF-κB), the surface expression of vascular cell adhesion molecule-1 (VCAM-1), the production of cytokines such as monocyte chemoattractant protein-1 and interleukin-6, and the number of mononuclear leukocytes adhering to ECs induced by tumor necrosis factor-α (TNF-α) and oxidized low-density lipoprotein (oxLDL). This suppressive effect was diminished by both a kinin B2 receptor antagonist and a nitric oxide synthase (NOS) inhibitor. These results indicated that quinaprilat reduced the activation of NF-κB under the stress of chemoattractants such as TNF-α and oxLDL through the increase of endothelial nitric oxide (NO) produced by activated endothelial nitric oxide synthase (eNOS) via a secondary accumulation of bradykinin in ECs. These results suggest an anti-atherogenic effect of ACE inhibitor.
