期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2004
卷号：34
期号：3
页码：89-94
DOI：10.3164/jcbn.34.89
出版社：The Society for Free Radical Research Japan
摘要：The present investigation was undertaken to study the effect of pretreatment with the methanolic extract of Asteracantha longifolia (AL) seeds on liver antioxidant defense system during acetaminophen-induced liver damage in rats. Acetaminopheninduced liver injury was manifested by a significant increase in the levels of lipid peroxides with a concomitant decrease in the levels of enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase) and non-enzymic antioxidants (reduced glutathione, vitamin C and vitamin E). Pretreatment with AL extract reversed these alterations to near normal. Results of the study confirm that pretreatment with AL seed extract is very effective in reducing acetaminophen-induced oxidative stress suggesting its antioxidant property.
