期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1988
卷号：5
期号：3
页码：231-239
DOI：10.3164/jcbn.5.231
出版社：The Society for Free Radical Research Japan
摘要：Effects of vitamin E (VE) on tumor growth and in vitro lymphocyte proliferation as markers of cellular immunity in CDF1 mice were examined in the VE-deficient state as well as in the VE-sufficient state attained by pretreatment with VE. Oral (585mg of dl-α-tocopheryl nicotinate per 100g diet) or intraperitoneal (0.5ml of saline-diluted d-α-tocopherol every other day at a dose of 40mg/kg) supplementation with VE did not enhance in vitro lymphocyte proliferation to concanavalin A, phytohemagglutinin, or lipopolysaccharide, suppress the growth of Meth A fibrosarcoma, or prolong the survival of tumor-bearing animals, even though the serum VE value was maintained 1.5 to 2.4 times higher in the group fed the VE-sufficient diet and about 3 times higher in the group injected with VE than the value for the group fed the control diet. On the other hand, VE-deficiency produced by a basal VE-deficient diet (0.16mg of d-α-tocopherol per 100g diet) seemed to be disadvantageous for the tumor-bearing host in view of the decrease in in vitro lymphocyte proliferation to phytohemagglutinin or lipopolysaccharide, rapid tumor growth, and shortened survival of tumor-bearing mice.
关键词：cellular immunity;tumor growth;vitamin E;mitogens;vitamin E deficiency
