期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：6
期号：2
页码：127-134
DOI：10.3164/jcbn.6.127
出版社：The Society for Free Radical Research Japan
摘要：Structure and function of rat liver microsomes were studied during biliary obstruction and after its relief by external drainage. The concentration of serum bilirubin and the activity of serum glutamic-oxaloacetic transaminase rapidly decreased to near normal levels after the drainage. The percentage of smooth endoplasmic reticulum to the total endoplasmic reticulum increased during the biliary obstruction but it returned to normal one day after the drainage. In contrast, the specific content of cytochrome P-450 and the specific activity of NADPH-cytochrome c reductase in the microsomes did not recover to normal ones even 10 days after the drainage. These results demonstrate that the dysfunction of liver microsomes is prolonged after bile drainage despite recovery of serum biochemical indices and ultrastructural changes to the normal state.
关键词：biliary obstruction;microsomes;cytochrome P-450;liver;NADPH-cytochrome c reductase
