期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：6
期号：3
页码：233-243
DOI：10.3164/jcbn.6.233
出版社：The Society for Free Radical Research Japan
摘要：This study evaluated the effects of a 10.5% mixture of glucose, fructose, and xylitol at a 4:2:1 ratio on the postoperative management of 15 patients with impaired glucose tolerance. Only 5 patients, who were diabetic or showed the diabetes mellitus pattern in the 75-g oral glucose tolerance test (OGTT), required insulin supplementation. In 3 of these patients it was possible to decrease the daily dose of insulin from 48 to 36IU/day, 28 to 24IU/day, and 19 to 15IU/day, respectively. Whereas, in the other two of these patients, one of them required a dose of 15IU/day on third postoperative day while the other required an increase from 22 to 48IU/day to achieve blood glucose control. In the other two patients with diabetes mellitus and 8 patients who showed a borderline pattern in the 75-g OGTT, blood glucose levels could be maintained under 200mg/dl without the use of insulin. We also found low stimulation of insulin release as shown by the serum insulin values and progressive diminution of urinary glucose excretion. This solution had an inhibitory effect on lipolysis as well as an antiketogenic effect. The infusion did not adversely affect renal or hepatic function and no patients developed lactic acidosis. Furthermore, there were no complications, and side effects related to the use of this solution were rare. We conclude that this mixture of glucose, fructose, and xylitol is safe and useful in the postoperative management of patients with impaired glucose tolerance.
