期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：7
期号：1
页码：53-58
DOI：10.3164/jcbn.7.53
出版社：The Society for Free Radical Research Japan
摘要：Adriamycin entrapped in small unilamellar vesicles (SUV-ADM) and that in multilamellar vesicles (MLV-ADM), composed of egg yolk phosphatidylcholine, cholesterol, and sulfatide in a molar ratio of 5:4:1, were examined for their effects on ovarian carcinoma AMOC-1 cells in comparison with free adriamycin. Cellular uptake and cytotoxicity were demonstrated for both SUV-ADM and MLV-ADM. The degrees of cellular uptake and cytotoxicity of SUV-ADM were comparable with those of free adriamycin, though those of MLV-ADM were somewhat lower than those of the free or SUV-entrapped drug. From these results and previous data obtained by pharmacokinetic study, the liposomes with the above composition are considered to be useful drug carriers for chemotherapy of ovarian tumors.
