期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1990
卷号：8
期号：2
页码：85-92
DOI：10.3164/jcbn.8.85
出版社：The Society for Free Radical Research Japan
摘要：The effect of anticancer drugs on superoxide dismutase (SOD) activity was investigated in two cancer cell lines (NA cells and HeLa S3 cells). The NA cells were derived from a squamous cell carcinoma of the tongue. Bleomycin, mitomycin C, cisplatin, and 5-fluorouracil were used as anticancer drugs. SOD activities in the cancer cells were found to be enhanced after administration of these drugs; SOD activity increased in a dose-dependent manner at concentrations from 1.2 to 30μg/ml of bleomycin, and reached maximum 6h after the administration of 2.0μg/ml of the drug. NaF, a glycolysis, inhibitor, enhanced SOD activity both in the presence and absence of bleomycin, while KCN decreased SOD activity significantly. NaF and bleomycin showed an additive effect. These results suggest that SOD activity may be enhanced by anticancer drugs through several mechanisms.
