期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1990
卷号：8
期号：2
页码：133-139
DOI：10.3164/jcbn.8.133
出版社：The Society for Free Radical Research Japan
摘要：The effects of lidocaine on cerebral metabolic changes during and after forebrain Ischemia (10min) in a rat model were studied by in vivo 31P-NMR spectroscopy. Rat brains were made ischemic for 10min by bleeding to 40mmHg with subsequent application of bilateral carotid artery occlusion. Forebrain Ischemia caused a decrease in intracellular high-energy phosphates and in intracellular pH (pHi) in both control and lidocaine-treated groups, but its extent was smaller in the lidocaine-treated group than in the control group. Moreover, lidocainetreated group showed a faster return to the preischemia level in cerebral energy metabolism than the control group after forebrain ischemia. Thus, lidocaine was shown by 31P-NMR spectroscopy to have a protective effect, particularly in relation to cerebral high-energy phosphates.
