期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1990
卷号：8
期号：3
页码：193-200
DOI：10.3164/jcbn.8.193
出版社：The Society for Free Radical Research Japan
摘要：Blood glucose levels of streptozocin (STZ)-induced diabetic rats dropped from hyperglycemic levels to hypoglycemic levels within 24-48h after treatment with vanadyl sulfate (VS) by intraperitoneal injection. Results of the glucose tolerance test indicated that the diabetes was completely improved by VS administration, but the plasma insulin levels were still low. Determination of both vanadyl and total vanadium in VS-treated STZ-rats suggested that the vanadyl is possibly in a pharmacologically active form. Several vanadyl complexes such as vanadyl-cysteine methyl ester (VCys), -oxalate (VOX), -malonate (VMA), -salicylaldehyde (VSA), and -(+)-tartarate (VTA) were tested by oral administration. The order of normoglycemic effect in STZ-rats was VA>VCys>VTA>VSA>VOX. The action of VCys was dose-dependent in the range of 1-10mgV/kg body weight, and this complex was shown to be a potent agent in restoring the normoglycemic level in STZ-induced diabetic rats.
