期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1990
卷号：8
期号：3
页码：201-207
DOI：10.3164/jcbn.8.201
出版社：The Society for Free Radical Research Japan
摘要：Guinea pigs given an adequate amount (2.0mg/100g/day) of ascorbic acid and treated with a potent chemical carcinogen, N-nitrosodiethylamine, showed significantly increased hepatic cytochrome P-450 levels without a change in arylhydrocarbon hydroxylase activity. In animals fed an excessive amount (50mg/100g/day) of ascorbic acid, N-nitrosodiethylamine administration significantly decreased hepatic and pulmonary arylhydrocarbon hydroxylase and cytochrome P-450 levels. However, the cytochrome c -reductase activity remained unaffected. Hepatic and pulmonary glutathione S-transferase and reduced glutathione levels responded differentially to N-nitrosodiethylamine challenge in the two groups of animals.
