期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1990
卷号：8
期号：3
页码：235-246
DOI：10.3164/jcbn.8.235
出版社：The Society for Free Radical Research Japan
摘要：This study assessed the biochemical status of serumα-tocopherol (Toc), retinol (Ret), and lipids in elementary school children (ages 9-12 years, 38 males and 37 females) and searched for relationships among them. No significant difference was observed between the sexes for total cholesterol (T-C) (165 and 163mg/100ml for males and females, respectively), high-density lipoprotein-cholesterol (HDL-C) (64 and 62mg/100ml), low-density lipoprotein-cholesterol (LDL-C) (101mg/100ml for both groups), or for triglycerides (TG) (79 and 77mg/100ml). Therefore, the percentage of HDL-C to T-C (39 and 38%) and the LDL-C/HDL-C ratio (1.67 and 1.68) were about the same for both sexes. Toc and Ret levels of males and females were 5.48 and 5.57μg/ml and 478 and 449ng/ml, respectively. The ratios of Toc/TG (7.50 and 7.93μg/mg) and Ret/TG (666 and 613ng/mg) also showed no significant differences. A correlation was found between the T-C level and LDL-C ( r =0.85, p<0.001) and also between it and the ratio of LDL-C/HDL-C ( r =0.42, p<0.001). The atherogenic index, LDL-C/HDL-C ratio, showed a negative correlation with the HDL-C level ( r =-0.73, p<0.001). The Toc level was positively correlated with the ratio of Toc/TG ( r =0.45, p<0.001), and the ratio of Toc/TG was inversely correlated with the TG level ( r =-0.80, p<0.001). Serum Ret levels showed a positive correlation with the ratios of Ret/TG ( r =0.63, p<0.001), and the Ret/TG ratio showed an inverse correlation with the TG level ( r =-0.56, p<0.001). The ratios of Toc/TG were positively correlated with the ratios of Ret/TG ( r =0.56, p<0.001), and these ratios showed a positive correlation With the HDL-C ( r =0.42, p<0.001; and r =0.36, p<0.01, respectively). These results reveal that relationships among the risk factors for coronary heart disease are the same in children as in adults and that the TG levels affect the relative nutritional status of vitamins E and A in serum. Thus, the ratios of Toc/TG and Ret/TG may be useful for assessment of hyperlipidemia in children.
