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  • 标题:Induction of Lipid Peroxidation in Rat Liver Microsomes by Catecholamine-Iron Complex
  • 本地全文:下载
  • 作者:Kunio YAGI ; Naoko ISHIDA ; Sadaaki KOMURA
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:1990
  • 卷号:9
  • 期号:3
  • 页码:179-184
  • DOI:10.3164/jcbn.9.179
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:Epinephrine and norepinephrine, when either formed a complex with iron, were able to induce lipid peroxidation in rat liver microsomes. The microsomal lipid peroxidation induced by them was NADPH-dependent. Adrenochrome, an oxidation product of epinephrine, was also able to induce microsomal lipid peroxidation in the presence of iron, but in this case it was mainly NADPH-independent. Catecholamines can be deleterious to biological systems, if they form complexes with iron and thus induce lipid peroxidation to some extent.
  • 关键词:lipid peroxidation;catecholamine-iron complex;rat liver microsomes
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