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  • 标题:Bacterial 7-dehydroxylation of cholic acid and allocholic acid
  • 本地全文:下载
  • 作者:Victor Bokkenheuser ; Takahiko Hoshita ; Erwin H. Mosbach
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:1969
  • 卷号:10
  • 期号:4
  • 页码:421-426
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes). The growth of the organism was inhibited by neomycin, 10-20 μg/ml. The existence of this organism affords a satisfactory explanation for the development of gallstones in the cholestanol-fed rabbit and for their absence in rabbits simultaneously treated with neomycin.
  • 关键词:deoxycholic acid ; allodeoxycholic acid ; gallstone ; rabbit ; anaerobe ; neomycin
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