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  • 标题:Synthesis of sn-glycero-1-phosphocholine.
  • 本地全文:下载
  • 作者:P Kanda ; M A Wells
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:1981
  • 卷号:22
  • 期号:5
  • 页码:879-882
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:The preparation of sn-glycero-1-phosphocholine is described. 2,3-O-Isopropylidene-sn-glycerol is condensed first with the 1,2-dimethylethenylene phosphorochloridate in the presence of triethylamine to yield the cyclic phosphotriester derivative. Choline p-toluenesulfonate, as the second alcohol, is condensed with this intermediate to yield the phosphotriester bearing the 1-methyl-acetonyl blocking group. This is removed under basic conditions to afford the 2,3-O-isopropylidene-sn-glycerol-1-phosphocholine in 57% yield following silicic acid column chromatography. The acetone blocking group is then removed with aqueous HCl (pH 2.3) to give pure sn-glycero-1-phosphocholine.
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