出版社：American Society for Biochemistry and Molecular Biology
摘要：Diether glycerophosphocholines containing one long and one short chain were synthesized in moderate yield. The synthesis of a diether glycerophosphocholine containing a branched chain and a straight chain is also described. Alkylation of fatty alcohol with allyl bromide and dimethyl sulfoxide anion gave fatty alkyl allyl ether, which was hydroxylated and tritylated. By procedures described previously, 1-O-alkyl-3-O-triphenyl-methylglycerol was alkylated, detritylated, and converted into the phosphocholine product. This method is of general utility for the preparation of a variety of mixed-chain racemic glycerophosphocholines whose physical properties are of interest in studies of biological membranes.
