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  • 标题:Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease.
  • 本地全文:下载
  • 作者:Y I Ahn ; M I Kamboh ; R F Hamman
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:1993
  • 卷号:34
  • 期号:3
  • 页码:421-428
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Lipoprotein lipase (LPL) plays a crucial role in plasma lipoprotein processing by catalyzing the hydrolysis of core triglycerides of chylomicrons and very low density lipoproteins. Several polymorphic restriction sites have been reported in the LPL gene, including those identified by the enzymes HindIII and PvuII. We have determined the HindIII and PvuII polymorphisms in diabetic (D) and non-diabetic (ND) Hispanics (D = 195; ND = 384) and non-Hispanic Whites (D = 76; ND = 539) from the San Luis Valley, Colorado. Both polymorphisms showed comparable gene frequencies between diabetics and non-diabetics, and between the two ethnic groups. The HindIII and PvuII polymorphisms were in strong linkage disequilibrium in both Hispanics and non-Hispanic Whites (P
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