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  • 标题:Heparin-induced lipolysis in hypertriglyceridemic subjects results in the formation of atypical HDL particles.
  • 本地全文:下载
  • 作者:N M O'Meara ; V G Cabana ; J R Lukens
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:1994
  • 卷号:35
  • 期号:12
  • 页码:2178-2190
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:This study reports on the characterization of high density lipoprotein (HDL) in normotriglyceridemic and hypertriglyceridemic (HTG) subjects, after a fat meal and heparin-induced release of lipases. Samples for detailed analysis of HDL by density gradient ultracentrifugation and nondenaturing gradient gel electrophoresis were collected at 0 h and 5 h after the meal and 15 min after the administration of heparin. The normotriglyceridemic subjects were subdivided into two groups: those who remained normotriglyceridemic 5 h after the meal (NTG) or those who were hypertriglyceridemic at this time point (NTG-HTG). At the outset of the study, mean triglyceride levels were significantly higher (P
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