出版社：American Society for Biochemistry and Molecular Biology
摘要：Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is found predominantly in adipose tissue and muscle. We examined the mechanism of regulation of LPL in muscles composed of different fiber types (soleus, extensor digitorum longus, and heart) in fed, fasted, and hypothyroid rats. In all muscles, the detergent-extractable (EXT) fraction represented approximately 95% of total LPL activity and mass. LPL activity was similar in the heparin-releasable (HR) fractions of heart and soleus (predominantly type I fibers), while in the EXT fraction LPL activity in soleus was 418 +/- 48 nEq/min per g, and in heart was 272 +/- 30 nEq/min per g (P
