出版社：American Society for Biochemistry and Molecular Biology
摘要：The objective of this study was to investigate the mobilization of individual fatty acids from human subcutaneous adipose tissue in vivo. Concentrations of individual non-esterified fatty acids were measured in arterialized plasma and in the venous drainage from subcutaneous abdominal adipose tissue in eight normal subjects, after an overnight fast, and for the subsequent 6 h. Whilst the veno-arterial concentration difference for non-esterified fatty acids increased over this period, the relative proportions of different fatty acids remained constant. There was a close relationship between veno-arterial difference and arterialized concentration for the different fatty acids. The arterialized concentration of stearic acid consistently lay above the regression line drawn for unsaturated fatty acids (P = 0.001), probably reflecting lower clearance of stearic acid. The release of individual fatty acids was compared with their prevalence in adipose tissue triacylglycerol in biopsies taken from six subjects. Relative release decreased with increasing chain length, and for a given chain length increased with increasing unsaturation, in agreement with animal studies (P
