标题：Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC)
出版社：American Society for Biochemistry and Molecular Biology
摘要：Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated. This study examined the relationship between hepatic lipase activity, plasma HDL-C concentrations, and a hepatic lipase polymorphism (–514T) in African American and white American men. Consistent with previous reports, plasma HDL-C concentrations were significantly higher in African American men than in white American men. Mean post-heparin plasma hepatic lipase activity was significantly lower in African American than in white American men (27 ± 12 vs. 44 ± 17 mmol • h–1 •l–1, P Vega, G. L., L. T. Clark, A. Tang, S. Marcovina, S. M. Grundy, and J. C. Cohen. Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene ( LIPC ). J. Lipid Res. 1998. 39: 228–232.
