出版社：American Society for Biochemistry and Molecular Biology
摘要：Studies on monozygotic twins support a role for genetic determinants of plasma lipid, lipoprotein, and apolipoprotein levels. Gene variants of the enzyme lipoprotein lipase have been shown to associate with dyslipidemia and coronary artery disease. We assessed the gene–environment interaction by investigating the relationship between the lipoprotein lipase gene and plasma lipid, lipoprotein, and apolipoprotein variability and levels among 54 male monozygotic twin pairs (aged 18–28 years). The Ser447–Ter mutation (C→G transversion) was associated with significantly smaller within-pair differences in plasma high density lipoprotein-cholesterol (CG [n = 10] vs. CC [n = 44], 3.7 ± 5.3 mg/dl vs. 6.4 ± 5.2 mg/dl, P P 447–Ter mutation exerts multiple effects. This study also raises the possibility of a genetically determined responsiveness to dyslipidemia therapies.— Thorn, J. A., E. W. A. Needham, R. K. Mattu, J. Stocks, and D. J. Galton. The Ser447–Ter mutation of the lipoprotein lipase gene relates to variability of serum lipid and lipoprotein levels in monozygotic twins. J. Lipid Res. 1998. 39: 437–441.
