标题：Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia
出版社：American Society for Biochemistry and Molecular Biology
摘要：Plasma triglyceride (TG) levels are inversely related to HDL-cholesterol levels and subjects with high TG and low HDL cholesterol have increased coronary heart disease (CHD) risk. Plasma cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from HDL to TG-rich lipoproteins. In this study we determined the relationship between a common CETP amino acid polymorphism (I405V) and CETP and HDL levels and CHD prevalence in 576 men of Japanese ancestry in the Honolulu Heart Program cohort. This conservative substitution was associated with altered plasma CETP concentration (1.95 ± 0.54, 1.91 ± 0.57, and 1.77 ± 0.57 μg/ml for the II , IV and VV genotypes, respectively). The distribution of plasma CETP concentrations among the VV , but not II , men appeared bimodal ( P VV than IV for II men (55.4 ± 17.4, 51.3 ± 16.6, 51.1 ± 17.0 mg/dl, P VV men with plasma TG > 165 mg/dl. Although CHD prevalence was not significantly different among the three genotypes in this population, in the subpopulation with high plasma TG, CHD prevalence appeared higher among VV than IV or II subjects (38% vs. 27% vs. 18%, P The data suggest that a widespread and common CETP gene mutation(s) in linkage disequilibrium with 405V causes low CETP. Among hypertriglyceridemic men this is associated with higher HDL and possibly with increased CHD.— Bruce, C., D. S. Sharp, and A. R. Tall. Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia. J. Lipid Res. 1998. 39: 1071–1078.
关键词：cholesteryl ester transfer protein ; lipid transfer protein ; high density lipoproteins ; hypertryiglyceridemia ; coronary heart disease
