出版社：American Society for Biochemistry and Molecular Biology
摘要：The lipoprotein lipase (LPL) promoter -93T/G transition has previously been reported as having a triglyceride (Tg)-lowering effect, whereas the D9N variant has been shown to have a Tg-raising effect. These two variants were studied in 66 healthy subjects of Hispanic and 42 subjects of African-American origin, who had participated in a study of postprandial lipemia. While the allele frequency of the -93G was significantly different in the Hispanics and African Americans (0.09: 95% CI 0.04–0.13 and 0.28: 95% CI 0.19–0.38; P = 0.0001, respectively), the N9 allele frequency was not different (0.06: 95% CI 0.02–0.1 and 0.05: 95% CI 0.002–0.093, respectively). Linkage disequilibrium between the -93T/G and D9N was highly significant in Hispanics (Δ = 0.67. P = 0.0001), compared to Δ = 0.09 (NS) in African-Americans. In the combined group, compared to individuals with the common genotype (TT/DD; n = 71) with fasting plasma Tg of 1.34 (±4.5% SEM) mmol/l, carriers of the G/D haplotype (TG/DD + GG/DD; n = 25) had significantly lower plasma Tg levels of 1.08 (±10% SEM) mmol/l ( P P P J. Lipid Res. 1998. 39: 1189–1196.
