出版社：American Society for Biochemistry and Molecular Biology
摘要：This study has assessed the influence of maternal n–3 long chain polyunsaturated fatty acid supply and dietary manipulation after weaning on the retinal polyunsaturated fatty acid profile. Infant guinea pigs born of dams fed one of two commercial chow diets (differing in the amount of eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids) were raised in two separate experiments, and subsequently partitioned into two diet groups, one supplied with a high level of alpha-linolenic acid (canola oil supplemented), the other with a very low level of alphalinolenic acid (safflower oil supplemented). Guinea pigs born of dams supplied with the longer chain n–3 fatty acids in the commercial pellets (experiment 2) showed higher levels of retinal docosahexaenoic acid at weaning compared with those born to dams fed chow containing only alphalinolenic acid (experiment 1). The rate of depletion of retinal docosahexaenoic acid after weaning onto the safflower oil diet was described by a two-stage exponential decay, possibly reflecting systemic and local conser vation mechanisms, in conditions of dietary n–3 fatty acid deprivation. The rate of docosahexaenoic acid depletion in the group with the lower retinal docosahexaenoic acid at weaning was more than double the rate of depletion in the group with the higher weaning docosahexaenoic acid value. The end-point retinal docosahexaenoic acid level at 16 weeks post-weaning after dietary n–3 fatty acid depletion on the safflower oil diet in the group, which started with the lower retinal docosahexaenoic acid level, was approximately half that compared with the group from the dams fed long chain n–3 fatty acids (experiment 1, 5% (interpolated), experiment 2, 9%). These results suggest that an adequately supplied mother is capable of providing an infant with enough n–3 fatty acids to withstand a longer period of dietary deprivation imposed after weaning.—Weisinger, H. S., A. J. Vingrys, L. Abedin, and A. J. Sinclair. Effect of diet on the rate of depletion of n–3 fatty acids in the retina of the guinea pig. J. Lipid Res. 1998. 39: 1274–1279.
