出版社：American Society for Biochemistry and Molecular Biology
摘要：To investigate whether dietary fat source and energy restriction interactively influence plasma leptin levels and its association of leptin with insulin action, rats were fed diets containing either fish, safflower oil, or beef tallow (20% wt/wt) for 10 weeks. Groups of rats consumed each diet ad libitum or at 85% or 70% of ad libitum energy intake in a design that held fat intake constant. Graded levels of energy restriction caused body weight to decrease ( P P P P These data demonstrate a hyperleptinemic effect in animals consuming diets rich in polyunsaturated fatty acid, which can be normalized to the level of saturated fat consumption by mild energy restriction. Thus, dietary fatty acid composition, independent of adipose tissue mass, is an important determinant of circulating leptin level in diet-induced obesity.—Cha, M. C., and P. J. H. Jones. Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. J. Lipid. Res. 1998. 39: 1655–1660.
关键词：fish oil ; safflower oil ; beef tallow ; energy restriction ; leptin ; insulin ; rat
