出版社：American Society for Biochemistry and Molecular Biology
摘要：Heterozygous familial hypercholesterolemia (FH) is associated with a moderate decrease of plasma apoA-I and HDL-cholesterol levels. The aim of the study was to test the hypothesis that these abnormalities were related to an increase of HDL-apoA-I fractional catabolic rate (FCR). We performed a 14-h infusion of [5,5,5-2H3]leucine in seven control subjects and seven heterozygous FH patients (plasma total cholesterol 422 ± 27 vs. 186 ± 42 mg/dL, P 2 and HDL3 subclasses. Both mean apoA-I FCR and absolute production rate (APR) were increased in FH (respectively, 0.36 ± 0.14 vs. 0.22 ± 0.05 pool/d, P P P P We conclude that the catabolism of HDL-apoA-I is increased in heterozygous FH patients. However, plasma apoA-I concentration was maintained because of an increased HDL-apoA-I production rate.— Frénais, R., K. Ouguerram, C. Maugeais, J. S. Marchini, P. Benlian, J. M. Bard, T. Magot, and M. Krempf. Apolipoprotein A-I kinetics in heterozygous familial hypercholesterolemia: a stable isotope study. J. Lipid Res. 1999 . 40: 1506–1511.
关键词：heterozygous familial hypercholesterolemia ; stable isotope ; kinetic analysis ; apo AI ; HDL
