出版社：American Society for Biochemistry and Molecular Biology
摘要：It has been suggested that phytosterol and phytostanol esters possess similar cholesterol-lowering properties, however, whether mechanisms responsible are identical has not been addressed. To address this question, cholesterol plasma levels, absorption, biosynthesis, and turnover were measured in 15 hypercholesterolemic subjects consuming prepared diets each over 21 d using a crossover design. Diets contained either i ) margarine (M), ii ) margarine with phytosterol esters (MSE) (1.84 g/d), or iii ) margarine with phytostanol esters (MSA) (1.84 g/d). Cholesterol absorption was measured using the ratio of [13C]cholesteroloral:D7-cholesterolIV; biosynthesis using D incorporation from D2O and turnover by D7-cholesterolIV decay rates. Plasma total cholesterol level at d 21/22 was lower ( P P P P —Jones, P. J., M. Raeini-Sarjaz, F. Y. Ntanios, C. A. Vanstone, J. Y. Feng, and W. E. Parsons. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J. Lipid Res. 2000. 41: 697–705.
