出版社：American Society for Biochemistry and Molecular Biology
摘要：To determine mechanisms by which hydrogenated fat influences plasma lipid levels, 14 women (65–71 yrs with LDL-C ≥ 130 mg·dl−1) consumed, for 5-week periods each, a baseline (BL) diet (39% kcal fat, 164 mg chol·1000 kcal−1) and reduced fat diets (30% kcal) where two-thirds of the fat was either soybean oil (SO), low trans squeeze (SQM), medium trans tub (TM), or high trans stick (SM) margarines, or butter (BT). Plasma lipid levels were analyzed at the end of each phase. Fractional synthesis rates (FSR) in pools/day (p·d−1) and absolute synthesis rates (ASR) in grams/day (g·d−1) of free cholesterol (FC) were measured using the deuterium incorporation methodology. Plasma total ( P P P trans SQM (0.081 ± 0.019 p·d−1) and medium trans TM (0.086 ± 0.029 p·d−1) diets elicited responses similar to the SO (0.078 ± 0.024 p·d−1) diet, whereas high trans SM (0.053 ± 0.029 p·d−1) diet mimicked the BT (0.062 ± 0.017 p·d−1) and high fat BL (0.053 ± 0.023 p·d−1) diet in its suppression ( P —Matthan, N. R., L. M. Ausman, A. H. Lichtenstein, and P. J. H. Jones. Hydrogenated fat consumption affects cholesterol synthesis in moderately hypercholesterolemic women. J. Lipid Res. 2000. 41: 834–839.
