标题：Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects
出版社：American Society for Biochemistry and Molecular Biology
摘要：Apolipoprotein L is a newly recognized component of human plasma lipoproteins. Mainly associated with apoA-I-containing lipoproteins, it is a marker of distinct HDL subpopulations. In an effort to gain inference as to its as yet unknown function, we studied biological determinants of apoL levels in human plasma. The distribution of apoL in normal subjects is asymmetric, with marked skewing toward higher values. No difference was found in apoL concentrations between males and females, but we observed an elevation of apoL in primary hypercholesterolemia (10.1 vs. 8.5 μg/mL in control), in endogenous hypertriglyceridemia (13.8 μg/mL, P P P P P P P P P P P = 0.001), and non-insulin-dependent diabetes mellitus (NIDDM) (0.548, P P —Duchateau, P. N., I. Movsesyan, S. Yamashita, N. Sakai, K-I. Hirano, S. A. Schoenhaus, P. M. O'Connor-Kearns, S. J. Spencer, R. B. Jaffe, R. F. Redberg, B. Y. Ishida, Y. Matsuzawa, J. P. Kane, and M. J. Malloy. Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects. J. Lipid Res. 2000. 41: 1231–1236.
