出版社：American Society for Biochemistry and Molecular Biology
摘要：Plasma apolipoprotein A-IV (apoA-IV) levels are found elevated in hypertriglyceridemic patients. However, the relationship between plasma apoA-IV level and postprandial lipemia is not well known and remains to be elucidated. Thus, our objective was to study the relationship between plasma apoA-IV and postprandial TG after an oral fat load test (OFLT). Plasma apoA-IV was measured at fast and during an OFLT in 16 normotriglyceridemic, normoglucose-tolerant android obese subjects (BMI = 34.6 ± 2.9 kg/m2) and 30 normal weight controls (BMI = 22.2 ± 2.3 kg/m2). In spite of not statistically different fasting plasma TG levels in controls and obese patients, the former group showed an altered TG response after OFLT, featuring increased nonchylomicron TG area under the curve (AUC) compared with controls (516 ± 138 vs. 426 ± 119 mmol/l·min, P P P r = 0.60, P = 0.001), AUC of chymomicron TG ( r = 0.45, P r = 0.62, P —Vergès, B., B. Guerci, V. Durlach, C. Galland-Jos, J. L. Paul, L. Lagrost, and P. Gambert. Increased plasma apoA-IV level is a marker of abnormal postprandial lipemia: a study in normoponderal and obese subjects. J. Lipid Res. 2001. 42: 2021–2029.
关键词：triglycerides ; oral fat load ; syndrome X ; kinetics
