出版社：American Society for Biochemistry and Molecular Biology
摘要：The objective of this study was to examine the postprandial response to an exogenous fat source in eight weight-stable postobese subjects (2–3 years after gastric bypass) and eight matched control women, using a stable isotope, [13C]oleate. After a high fat breakfast meal (1,062 cal, 67% fat), [13C]oleate in triglyceride (TG)-rich lipoproteins (Sf >400 and Sf 20–400) and nonesterified fatty acids (NEFA), and 13C in breath CO2, were monitored over 8 h. There were no differences in resting energy expenditure, thermic effect of food, carbohydrate/fat oxidation ratio, breath 13CO2 enrichment, or fecal fat content between postobese and control subjects. Postprandially, there was no difference in Sf 20–400 TG or NEFA, but postobese subjects had lower Sf >400 incremental area under the curve (AUC) (−33%, P P 13C in Sf >400 TG returned to fasting levels 4 h earlier in postobese subjects and was lower than in control subjects at 4 and 6 h ( P 13C]NEFA profiles. In control subjects [13C]NEFA increased markedly over 8 h; postobese subject [13C]NEFA remained close to fasting nonenriched values, and was strikingly lower than in control subjects (72% lower by AUC, P P P —Faraj, M., P. Jones, A. D. Sniderman, and K. Cianflone. Enhanced dietary fat clearance in postobese women. J. Lipid Res. 2001. 42: 571–580.
