出版社：American Society for Biochemistry and Molecular Biology
摘要：We have studied metabolism of plant sterols and squalene administered intravenously in the form of lipid emulsion mimicking chylomicrons (CM). The CM-like lipid emulsion was prepared by dissolving squalene in commercially available Intralipid®. The emulsion was given as an intravenous bolus injection of 30 ml containing 6.3 mg of cholesterol, 1.9 mg of campesterol, 5.7 mg of sitosterol, 1.6 mg of stigmasterol, 18.1 mg of squalene, and 6 g of triglycerides in six healthy volunteers. Blood samples were drawn from the opposite arm before and serially 2.5–180 min after the injections. The decay of CM squalene, plant sterols, and triglycerides was monoexponential. The half-life of CM squalene was 74 ± 8 min, that of campesterol was 37 ± 5 min ( P P P P —Relas, H., H. Gylling, and T. A. Miettinen. Fate of intravenously administered squalene and plant sterols in human subjects. J. Lipid Res. 2001. 42: 988–994.
