出版社：American Society for Biochemistry and Molecular Biology
摘要：The nuclear receptor PPARγ is a central regulator of adipose tissue development and an important modulator of gene expression in a number of specialized cell types including adipocytes, epithelial cells, and macrophages. PPARγ signaling pathways impact both cellular and systemic lipid metabolism and have links to obesity, diabetes, and cardiovascular disease. The ability to activate this receptor with small molecule ligands has made PPARγ an attractive target for intervention in human metabolic disease. As our understanding of PPARγ biology has expanded, so has the therapeutic potential of PPARγ ligands. Recent studies have provided insight into the paradoxical relationship between PPARγ and metabolic disease and established new paradigms for the control of lipid metabolism. This review focuses on recent advances in PPARγ biology in the areas of adipocyte differentiation, insulin resistance, and atherosclerosis. —Walczak, R., and P. Tontonoz. PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism. J. Lipid. Res. 2002. 43: 177–186.
